ISMARA results for ENCODE cell lines, H3K36me3, averaged replicates (Ernst 2011)

ISMARA - Integrated System for Motif Actitivity Response Analysis is a free online tool that recognizes most important transcription factors that are changing their activity in a set of samples.

Averaging sample configuration

Sample Condition
Rep1_GM12878 GM12878
Rep1_HepG2 HepG2
Rep1_HMEC HMEC
Rep1_HSMM HSMM
Rep1_Huvec Huvec
Rep1_K562 K562
Rep1_NHEK NHEK
Rep1_NHLF NHLF
Rep2_GM12878 GM12878
Rep2_HepG2 HepG2
Rep2_HMEC HMEC
Rep2_HSMM HSMM
Rep2_Huvec Huvec
Rep2_K562 K562
Rep2_NHEK NHEK
Rep2_NHLF NHLF

All motifs sorted by activity significance

Motif name Z-value Associated genes Profile Logo
IRF1,2,7.p3 4.882 IRF1 (MAR, IRF-1)
IRF2 (IRF-2, DKFZp686F0244)
IRF7 (IRF7A, IRF-7H)
TEAD1.p2 4.430 TEAD1 (TEF-1)
TEAD2 (ETF, TEF4, TEF-4, TEAD-2)
TEAD3 (TEF5, TEAD5, TEF-5, DTEF-1, ETFR-1, TEAD-3)
TEAD4 (TEF3, RTEF1, TEF-3, EFTR-2, TEFR-1, TCF13L1, hRTEF-1B)
HNF1A.p2 4.198 HNF1A (HNF1, LFB1)
HIC1.p2 3.695 HIC1 (ZBTB29)
TFAP2{A,C}.p2 3.674 TFAP2C (AP2-GAMMA, ERF1, TFAP2G, hAP-2g)
TFAP2A (AP-2)
SPI1.p2 3.614 SPI1 (PU.1, SPI-A, OF, SFPI1, SPI-1)
SNAI1..3.p2 3.432 SNAI2 (SLUGH1)
SNAI1 (SNA, SLUGH2, SNAH)
SNAI3 (SMUC, Zfp293)
FOS_FOS{B,L1}_JUN{B,D}.p2 3.272 FOS (c-fos, AP-1)
JUNB
FOSL1 (fra-1)
JUND (AP-1)
FOSB (G0S3, GOSB, GOS3, AP-1, MGC42291, DKFZp686C0818)
KLF12.p2 3.240 KLF12 (AP-2rep, HSPC122, AP2REP)
HNF4A_NR2F1,2.p2 3.201 NR2F1 (EAR-3, COUP-TFI, TCFCOUP1, SVP44)
NR2F2 (COUP-TFII, COUPTFB, SVP40)
HNF4A (NR2A1, HNF4)
HOX{A6,A7,B6,B7}.p2 3.132 HOXB6
HOXA7
HOXB7
HOXA6
TFCP2.p2 3.054 TFCP2 (CP2, LSF, LBP-1C, TFCP2C)
TLX1..3_NFIC{dimer}.p2 3.006 TLX1
TLX3 (RNX)
PITX1..3.p2 2.907 PITX2 (IGDS, RS, Brx1, Otlx2, ARP1)
PITX3
PITX1 (PTX1, POTX)
GATA1..3.p2 2.682 GATA1 (ERYF1, NFE1)
GATA2 (NFE1B)
GATA3 (HDR)
RXR{A,B,G}.p2 2.392 RXRA (NR2B1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
SRF.p3 2.379 SRF (MCM1)
SPIB.p2 2.329 SPIB (SPI-B)
EP300.p2 2.245 EP300 (p300, KAT3B)
MYB.p2 2.244 MYB (c-myb)
YY1.p2 2.195 YY1 (NF-E1, DELTA, UCRBP, YIN-YANG-1, INO80S)
NFE2L2.p2 2.189 NFE2L2 (NRF2)
FEV.p2 2.182 FEV (PET-1, HSRNAFEV)
NFY{A,B,C}.p2 2.160 NFYC (CBF-C)
NFYB (CBF-A, HAP3)
NFYA (HAP2, CBF-B)
bHLH_family.p2 2.159 ARNTL (MOP3, JAP3, BMAL1, PASD3, bHLHe5)
MITF (WS2A, MI, bHLHe32)
MXI1 (MXD2, MAD2, MXI, bHLHc11)
TFE3 (TFEA, bHLHe33)
CLOCK (KIAA0334, KAT13D, bHLHe8)
OLIG2 (RACK17, OLIGO2, bHLHe19)
MXD4 (MAD4, MSTP149, MST149, bHLHc12)
HEY2 (bHLHb32)
HEY1 (HESR-1, CHF2, HESR1, HRT-1, CHF-2, HERP2, BHLHb31)
HEYL (bHLHb33)
MLXIPL (WS-bHLH, MIO, CHREBP, MONDOB)
HES6 (bHLHc23)
MXD3 (MAD3, bHLHc13)
ARNTL2 (BMAL2, MOP9, CLIF, PASD9, bHLHe6)
ID1 (dJ857M17.1.2, bHLHb24)
MNT (ROX, MXD6, MAD6, bHLHd3)
OLIG1 (BHLHB6, bHLHe21)
NPAS2 (MOP4, PASD4, bHLHe9)
ZNF423.p2 2.084 ZNF423 (KIAA0760, OAZ, Roaz, Ebfaz, Zfp104)
ZNF238.p2 2.058 ZNF238 (C2H2-171, TAZ-1, RP58, ZBTB18)
MTF1.p2 2.034 MTF1
GTF2A1,2.p2 2.013 GTF2A1 (TFIIA)
GTF2A2 (TFIIA, HsT18745)
POU2F1..3.p2 1.922 POU2F2 (OCT2)
POU2F1 (OCT1)
POU2F3 (OCT11, PLA-1, Skn-1a, Epoc-1)
TLX2.p2 1.906 TLX2 (Enx, Tlx2, NCX)
NFE2L1.p2 1.871 NFE2L1 (NRF1, LCR-F1, FLJ00380, TCF11)
HBP1_HMGB_SSRP1_UBTF.p2 1.842 HMGB2
HMGB3 (HMG2A, MGC90319)
SSRP1 (FACT80)
UBTF (UBF, NOR-90)
HBP1
MZF1.p2 1.832 MZF1 (MZF1B, ZSCAN6, MZF-1, Zfp98)
PAX4.p2 1.763 PAX4
NR5A1,2.p2 1.750 NR5A1 (FTZ1, SF-1, ELP, AD4BP)
NR5A2 (FTZ-F1beta, hB1F, LRH-1, FTZ-F1, hB1F-2, B1F2)
PRDM1.p3 1.729 PRDM1 (PRDI-BF1)
E2F1..5.p2 1.705 E2F4 (E2F-4)
E2F5
E2F2 (E2F-2)
E2F1 (RBP3)
E2F3
RUNX1..3.p2 1.697 RUNX1 (PEBP2A2, AMLCR1)
RUNX3 (AML2, PEBP2A3)
RUNX2 (AML3, PEBP2A1, PEBP2aA1)
GLI1..3.p2 1.690 GLI1
GLI2 (THP2, HPE9, THP1)
GLI3 (PAP-A, PAPA, PAPA1, PAPB, ACLS, PPDIV)
ZEB1.p2 1.673 ZEB1 (BZP, ZEB, AREB6, NIL-2-A, Zfhep, Zfhx1a)
ESR1.p2 1.658 ESR1 (NR3A1, Era)
GFI1.p2 1.658 GFI1
BPTF.p2 1.638 BPTF (FAC1, NURF301)
TGIF1.p2 1.613 TGIF1
PRRX1,2.p2 1.612 PRRX2 (PRX2, PMX2)
PRRX1 (PHOX1)
FOXA2.p3 1.604 FOXA2
POU1F1.p2 1.596 POU1F1 (GHF-1)
NKX3-2.p2 1.595 NKX3-2 (NKX3B, NKX3.2)
HES1.p2 1.593 HES1 (FLJ20408, HES-1, Hes1, bHLHb39)
ZBTB16.p2 1.589 ZBTB16 (PLZF)
MYOD1.p2 1.588 MYOD1 (PUM, MYOD, bHLHc1)
KLF4.p3 1.581 KLF4 (EZF, GKLF)
DBP.p2 1.576 DBP (DABP)
MEF2{A,B,C,D}.p2 1.559 MEF2A (RSRFC4, RSRFC9)
MEF2C
MEF2D
MEF2BNB-MEF2B (MEF2B, LOC729991-MEF2B)
MEF2B (RSRFR2, FLJ32648)
HLF.p2 1.551 HLF (MGC33822)
GATA6.p2 1.545 GATA6
NFIX.p2 1.543 NFIX (NF1A)
CTCF.p2 1.519 CTCF
NHLH1,2.p2 1.512 NHLH1 (NSCL, NSCL1, bHLHa35)
NHLH2 (NSCL2, bHLHa34)
EN1,2.p2 1.511 EN1
EN2
TFDP1.p2 1.508 TFDP1 (Dp-1, DRTF1, DP1)
AHR_ARNT_ARNT2.p2 1.484 ARNT (HIF-1beta, bHLHe2)
AHR
ARNT2 (KIAA0307, bHLHe1)
JUN.p2 1.475 JUN (c-Jun, AP-1)
JUND (AP-1)
JUNB
RFX1..5_RFXANK_RFXAP.p2 1.466 RFX1 (EF-C)
RFXAP
RFX5
RFXANK (BLS, RFX-B, ANKRA1, F14150_1, MGC138628)
RFX4
RFX3
RFX2 (FLJ14226)
ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2 1.466 ARNT (HIF-1beta, bHLHe2)
MAX (bHLHd4)
MYC (c-Myc, bHLHe39)
USF1 (UEF, MLTFI, bHLHb11)
BHLHB2 (DEC1, bHLHe40)
ARNT2 (KIAA0307, bHLHe1)
NFATC1..3.p2 1.465 NFATC3 (NFAT4, NFATX)
NFATC2 (NF-ATP, NFATp, NFAT1)
NFATC1 (NF-ATC, NFATc, NFAT2)
DMAP1_NCOR{1,2}_SMARC.p2 1.461 SMARCA1 (SNF2LB, NURF140, ISWI, SWI)
SMARCC2 (BAF170, Rsc8, CRACC2)
SMARCA5 (hSNF2H, hISWI, ISWI)
NCOR1 (N-CoR, hCIT529I10, TRAC1, hN-CoR, KIAA1047, MGC104216)
NCOR2 (SMRT, SMRTE, TRAC-1, CTG26, TNRC14)
DMAP1 (DNMAP1, FLJ11543, KIAA1425, DNMTAP1, EAF2, SWC4)
SMAD1..7,9.p2 1.451 SMAD5 (Dwfc, JV5-1)
SMAD1 (MADR1, JV4-1)
SMAD3 (JV15-2, HsT17436)
SMAD4 (DPC4)
SMAD2 (MADR2, JV18-1)
SMAD6 (HsT17432)
SMAD7
SMAD9
ZFP161.p2 1.450 ZFP161 (ZNF478, ZBTB14)
TFEB.p2 1.439 TFEB
SOX{8,9,10}.p2 1.434 SOX9 (SRA1)
SOX8
SOX10 (DOM, WS4, WS2E)
GFI1B.p2 1.433 GFI1B
ONECUT1,2.p2 1.431 ONECUT2 (OC-2)
ONECUT1 (HNF-6)
SOX17.p2 1.427 SOX17
ZBTB6.p2 1.390 ZBTB6 (ZID)
MAFB.p2 1.378 MAFB
POU3F1..4.p2 1.367 POU3F1 (OCT6, SCIP)
POU3F3 (BRN1, OTF8)
POU3F2 (POUF3, BRN2, OCT7)
POU3F4 (BRN4, OTF9)
ZNF148.p2 1.365 ZNF148 (BERF-1, ZBP-89, BFCOL1, HT-BETA, ZFP148, pHZ-52)
SRY.p2 1.362 SRY (TDF)
ATF6.p2 1.354 ATF6 (ATF6A)
LMO2.p2 1.332 LMO2 (TTG2, RHOM2, RBTN2)
NFIL3.p2 1.327 NFIL3 (E4BP4, NFIL3A, NF-IL3A)
MYBL2.p2 1.309 MYBL2 (BMYB, B-MYB)
ATF5_CREB3.p2 1.308 ATF5
CREB3 (LZIP, Luman)
FOXQ1.p2 1.299 FOXQ1 (HFH1)
PAX5.p2 1.295 PAX5 (BSAP)
POU5F1_SOX2{dimer}.p2 1.281 POU5F1 (OCT3, Oct4, MGC22487)
SOX2
STAT2,4,6.p2 1.275 STAT2 (STAT113)
STAT4
STAT6 (D12S1644, IL-4-STAT)
NFKB1_REL_RELA.p2 1.272 RELA (p65)
REL (I-Rel)
NFKB1 (KBF1, p105)
FOX{I1,J2}.p2 1.267 FOXI1 (FREAC6)
FOXJ2 (FHX)
LEF1_TCF7_TCF7L1,2.p2 1.267 TCF7 (TCF-1)
TCF7L2 (TCF-4)
LEF1 (TCF1ALPHA)
TCF7L1
NKX3-1.p2 1.265 NKX3-1 (NKX3.1, BAPX2)
SREBF1,2.p2 1.261 SREBF1 (SREBP1, bHLHd1)
SREBF2 (SREBP2, bHLHd2)
IKZF1.p2 1.257 IKZF1 (hIk-1, LyF-1, Hs.54452, IKAROS)
FOXD3.p2 1.244 FOXD3 (Genesis, HFH2)
FOXL1.p2 1.236 FOXL1 (FREAC7, FKH6)
EGR1..3.p2 1.233 EGR3 (PILOT)
EGR1 (TIS8, G0S30, NGFI-A, KROX-24, ZIF-268, AT225, ZNF225)
EGR2
LHX3,4.p2 1.230 LHX3
LHX4 (Gsh4)
SP1.p2 1.224 SP1
POU6F1.p2 1.220 POU6F1 (BRN5, MPOU, TCFB1)
TBP.p2 1.216 TBP (TFIID)
SOX2.p2 1.190 SOX2
ZIC1..3.p2 1.175 ZIC1 (ZIC, ZNF201)
ZIC2 (HPE5)
ZIC3 (HTX, ZNF203)
ESRRA.p2 1.170 ESRRA (ERR1, ERRalpha, NR3B1, ERRa)
ATF4.p2 1.159 ATF4 (TAXREB67, CREB-2)
ZNF384.p2 1.152 ZNF384 (CAGH1A, CIZ, NMP4, NP)
ELK1,4_GABP{A,B1}.p3 1.152 GABPA (E4TF1A, NFT2, NRF2, E4TF1-60, NRF2A)
GABPB1 (E4TF1-47, GABPB)
ELK4 (SAP1)
ELK1
RXRA_VDR{dimer}.p2 1.130 VDR (NR1I1)
TCF4_dimer.p2 1.109 TCF4 (E2-2, ITF2, PTHS, SEF2, SEF2-1, SEF2-1A, SEF2-1B, bHLHb19, MGC149723, MGC149724)
TFAP4.p2 1.108 TFAP4 (AP-4)
EHF.p2 1.108 EHF
HSF1,2.p2 1.103 HSF1 (HSTF1)
HSF2
BACH2.p2 1.097 BACH2
FOX{D1,D2}.p2 1.094 FOXD2 (FREAC9)
FOXD1 (FREAC4)
HMGA1,2.p2 1.081 HMGA1
HMGA2 (BABL, LIPO)
CRX.p2 1.080 CRX (CRD, LCA7, OTX3)
ATF2.p2 1.079 ATF2 (TREB7, CRE-BP1, HB16)
HOX{A4,D4}.p2 1.052 HOXA4
HOXD4
MSX1,2.p2 1.050 MSX1 (HYD1, OFC5)
MSX2 (CRS2, FPP, HOX8, MSH, PFM)
NR1H4.p2 1.024 NR1H4 (FXR, RIP14, HRR1, HRR-1)
CREB1.p2 1.020 CREB1
FOX{F1,F2,J1}.p2 0.997 FOXF2 (FREAC2)
FOXJ1 (HFH-4, HFH4)
FOXF1 (FREAC1)
RXRG_dimer.p3 0.996 NR1H2 (NER, NER-I, RIP15, LXR-b)
RXRA (NR2B1)
PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
PPARA (hPPAR, NR1C1)
RXRB (NR2B2, H-2RIIBP, RCoR-1)
RXRG (NR2B3)
NKX6-1,2.p2 0.996 NKX6-1 (Nkx6.1)
NKX6-2 (NKX6B, GTX, NKX6.1)
MAZ.p2 0.989 MAZ (ZF87, Pur-1, Zif87, ZNF801)
MYFfamily.p2 0.974 MYOD1 (PUM, MYOD, bHLHc1)
MYF6 (MRF4, bHLHc4)
MYF5 (bHLHc2)
MYOG (bHLHc3)
CEBPA,B_DDIT3.p2 0.970 DDIT3 (CHOP10, GADD153, CHOP)
CEBPA (C/EBP-alpha)
CEBPB (LAP, CRP2, NFIL6, IL6DBP)
EVI1.p2 0.946 EVI1 (MDS1-EVI1, PRDM3)
NFE2.p2 0.934 NFE2 (NF-E2)
ZNF143.p2 0.930 ZNF143 (SBF, pHZ-1, STAF)
AIRE.p2 0.928 AIRE (PGA1, APS1)
FOXN1.p2 0.923 FOXN1 (FKHL20)
ETS1,2.p2 0.916 ETS2
ETS1 (FLJ10768, ETS-1)
EOMES.p2 0.915 EOMES (TBR2)
AR.p2 0.908 AR (AIS, NR3C4, SMAX1, HUMARA)
CDC5L.p2 0.902 CDC5L (PCDC5RP, hCDC5, CEF1)
PBX1.p2 0.894 PBX1
HIF1A.p2 0.893 HIF1A (MOP1, HIF-1alpha, PASD8, HIF1)
NKX2-3_NKX2-5.p2 0.893 NKX2-5 (CSX1, NKX2.5, NKX4-1)
NKX2-3 (NKX2.3, CSX3, NKX4-3)
TBX4,5.p2 0.882 TBX5
TBX4
GTF2I.p2 0.878 GTF2I (TFII-I, BAP-135, SPIN, BTKAP1, DIWS, IB291)
XBP1.p3 0.874 XBP1
SOX5.p2 0.845 SOX5 (L-SOX5, MGC35153)
NRF1.p2 0.844 NRF1 (EWG, ALPHA-PAL)
HMX1.p2 0.837 HMX1 (H6, NKX5-3)
HOX{A5,B5}.p2 0.832 HOXB5
HOXA5
ARID5B.p2 0.827 ARID5B (FLJ21150, MRF2)
FOXO1,3,4.p2 0.826 FOXO1 (FKH1)
FOXO4 (AFX1)
FOXO3 (AF6q21, FOXO2)
STAT1,3.p3 0.821 STAT1 (STAT91, ISGF-3)
STAT3 (APRF)
NANOG.p2 0.806 NANOG (FLJ12581, FLJ40451)
TFAP2B.p2 0.805 TFAP2B (AP2-B)
PAX2.p2 0.791 PAX2
SPZ1.p2 0.783 SPZ1 (NYD-TSP1, FLJ25709)
PPARG.p2 0.766 PPARG (PPARG1, PPARG2, NR1C3, PPARgamma)
CDX1,2,4.p2 0.762 CDX1
CDX2
CDX4
NANOG{mouse}.p2 0.748 NANOG (FLJ12581, FLJ40451)
FOSL2.p2 0.744 FOSL2 (FRA2, FLJ23306)
T.p2 0.739 T
PATZ1.p2 0.738 PATZ1 (MAZR, dJ400N23, ZBTB19, ZSG, RIAZ, PATZ)
TAL1_TCF{3,4,12}.p2 0.736 TCF3 (E2A, ITF1, MGC129647, MGC129648, bHLHb21)
TCF4 (SEF2-1B, ITF2, bHLHb19)
TAL1 (SCL, bHLHa17)
TCF12 (HEB, HTF4, HsT17266, bHLHb20)
EWSR1-FLI1.p2 0.732 FLI1 (EWSR2, SIC-1)
EWSR1 (EWS, K984G1.4)
POU5F1.p2 0.731 POU5F1 (OCT3, Oct4, MGC22487)
RBPJ.p2 0.729 RBPJ (SUH, IGKJRB, RBPJK, KBF2, RBP-J, CBF1)
EBF1.p2 0.725 EBF1 (OLF1)
NKX2-1,4.p2 0.715 NKX2-1 (TTF-1)
NKX2-4 (NKX2.4)
NR3C1.p2 0.713 NR3C1 (GR)
HAND1,2.p2 0.709 HAND1 (eHand, Thing1, Hxt, bHLHa27)
HAND2 (dHand, Thing2, Hed, bHLHa26)
STAT5{A,B}.p2 0.704 STAT5B
STAT5A (MGF)
RREB1.p2 0.683 RREB1 (HNT)
NR6A1.p2 0.674 NR6A1 (GCNF1, RTR)
ELF1,2,4.p2 0.671 ELF2 (EU32, NERF, NERF-2, NERF-1A, NERF-1B)
ELF1
ELF4 (MEF, ELFR)
ADNP_IRX_SIX_ZHX.p2 0.661 SIX5
ZHX1
IRX4
ADNP (KIAA0784, ADNP1)
ZHX3 (KIAA0395)
ZHX2 (KIAA0854)
IRX5 (IRX-2a)
SIX2
ALX1.p2 0.655 ALX1
HOXA9_MEIS1.p2 0.654 MEIS1
HOXA9
FOXP3.p2 0.614 FOXP3 (JM2, XPID, AIID, PIDX, DIETER, SCURFIN)
RORA.p2 0.584 RORA (RZRA, ROR1, ROR2, ROR3, NR1F1)
NKX2-2,8.p2 0.561 NKX2-2 (NKX2.2)
NKX2-8 (NKX2.8, Nkx2-9)
TP53.p2 0.504 TP53 (p53, LFS1)
FOX{C1,C2}.p2 0.503 FOXC1 (FREAC3, ARA, IGDA, IHG1)
FOXC2 (MFH-1)
PDX1.p2 0.502 PDX1 (IDX-1, STF-1, PDX-1, MODY4)
IKZF2.p2 0.490 IKZF2 (Helios)
GZF1.p2 0.448 GZF1 (dJ322G13.2, ZBTB23)
VSX1,2.p2 0.428 VSX2 (RET1)
VSX1 (PPD)
CUX2.p2 0.418 CUX2 (KIAA0293, CDP2)
REST.p3 0.337 REST (NRSF, XBR)
PAX6.p2 0.229 PAX6 (D11S812E, AN, WAGR)
PAX8.p2 0.182 PAX8
PAX3,7.p2 0.101 PAX7 (Hup1)
PAX3 (HUP2)

All samples sorted alphabetically


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Sample name Condition Replicate/Batch
GM12878
HepG2
HMEC
HSMM
Huvec
K562
NHEK
NHLF